6-Methoxy-2-(1-cyclohexenyl)benzo[b]thiophene → 6-Methoxy-2-cyclohexylbenzo[b]thiophene
反応式
[C:1]1([C:7]2[S:11][C:10]3[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:9]=3[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1>[Pd].C(OCC)(=O)C>[CH:1]1([C:7]2[S:11][C:10]3[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:9]=3[CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
4
実験手順
The product from Example 19, Step 1 (264 mg) and 10% Palladium on Carbon (60 mg) in 30 mL of ethyl acetate was added to a Parr shaker flask and hydrogenated at 50 psi for 16 hrs. at room temperature. The mixture was filtered over celite and concentrated. The crude product was chromatographed on silica gel using Hexanes as the eluant to give 210 mg of the title compound.
後処理
- customat room temperature
- filtrationThe mixture was filtered over celite and
- concentrationconcentrated
- customThe crude product was chromatographed on silica gel
出典と根拠
- ORDレコード
- ord-2c077a95b394429ebdf2ebb1d871f618
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06756388B1
反応ノート
読み込み中…