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(1-Benzylpiperidin-2-yl)methanol → [4-(1-Benzyl-piperidine-2-ylmethoxy)-phenyl]-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1-Benzylpiperidin-2-yl)methanol | HCID 2735486 | — |
| 反応物 | 2-(4-Methoxyphenyl)-3-(4-Hydroxybenzoyl)-6-Methoxybenzo[b]thiophene | HCID 9865197 | — |
| 生成物 | [4-(1-Benzyl-piperidine-2-ylmethoxy)-phenyl]-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone | HCID 23512907 | 36% |
反応手順
The product from Step 2 (600 mg) was coupled with (1-benzyl-piperidin-2-yl)-methanol (379 mg) as is Example 10, Step 3 to yield the title compound (320 mg) after silica gel chromatography with 10% ethyl acetate/hexanes to 20% ethyl acetate/hexanes as the gradient eluant.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06756388B1 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-9b2015e6bfd948daacd0faf5365a3720 |
| 出典メモ | uspto-grants-2004_06 |