Sulfuric Acid → 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

HRID 35412

反応式

HRID 35412 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH2:6][CH2:5]2.[Cl:11][CH2:12][C:13]([NH:15][CH2:16]O)=[O:14].S(=O)(=O)(O)O>C(O)(=O)C>[Cl:11][CH2:12][C:13]([NH:15][CH2:16][C:10]1[CH:9]=[C:8]2[C:4]([CH2:5][CH2:6][CH2:7]2)=[CH:3][C:2]=1[OH:1])=[O:14]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 151185-IndanolHCID 62466N-Methylol-alpha-chloroacetamide

生成物 1

HCID 212969152-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

134 g (1 mole) of 5-hydroxyindane and 100 g (0.81 mole) of 2-chloro-N-hydroxymethylacetamide are suspended in 300 ml of glacial acetic acid, and 10 ml of concentrated sulfuric acid are added. The mixture is stirred for 30 minutes at room temperature and is poured into ice water. The product is filtered off with suction and recrystallized from methanol.

後処理

  1. filtrationThe product is filtered off with suction
  2. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-9f24ddb28e444a7a9f35cd26d6f49873
出典データセット
uspto-grants-1988_08
特許番号
US04766241

関連ノート

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