Chlorosulfonic acid → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

HRID 35413

反応式

HRID 35413 の反応式
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[CH:9][C:8]=1[OH:16])=[O:4].[Cl:17][S:18](O)(=[O:20])=[O:19]>>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:18]([Cl:17])(=[O:20])=[O:19])[C:8]=1[OH:16])=[O:4]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 212969152-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

生成物 1

HCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

実験手順

70 g (0.29 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxyindane are dissolved in 150 ml of chlorosulfonic acid, and the mixture is stirred for approx. 30 minutes at room temperature. The mixture is poured into ice water and the product is filtered off with suction. The initially crystalline material becomes oily after a little time and is employed in the next stage in this form without further purification.

後処理

  1. filtrationthe product is filtered off with suction
  2. customis employed in the next stage in this form without further purification

出典と根拠

ORDレコード
ord-602c8eb7a33141f29baf3356b4e49d0a
出典データセット
uspto-grants-1988_08
特許番号
US04766241

関連ノート

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