3-Chloro-2-methylanisole → 3-Chloro-o-cresol

HRID 354261

反応式

HRID 354261 の反応式
[Cl:1][C:2]1[C:3]([CH3:10])=[C:4]([O:8]C)[CH:5]=[CH:6][CH:7]=1>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:3]([CH3:10])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 1

HCID 767493-Chloro-2-methylanisole

生成物 1

HCID 148563-Chloro-o-cresol

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

3.1 g (0.02 mol) of 3-chloro-2-methylanisole are heated in 20 ml of 50% sulphuric acid for 18 hours with reflux. After cooling, the reaction mixture is extracted three times with dichloromethane, dried over sodium sulphate and concentrated to dryness under reduced pressure. 3-Chloro-2-methylphenol is obtained as a solid (2.9 g, content by HPLC: 11.7%, 12% of theory).

後処理

  1. temperaturewith reflux
  2. temperatureAfter cooling
  3. extractionthe reaction mixture is extracted three times with dichloromethane
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-4f149bc2b5f84728ba42e39fa0b4c854
出典データセット
uspto-grants-2004_06
特許番号
US06756512B2

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