Hydrochloric Acid → 3-Amino-4-fluorobutanoic acid hcl
反応式
[F:1][CH2:2][CH:3]([NH:8]C(OC(C)(C)C)=O)[CH2:4][C:5]([OH:7])=[O:6].[ClH:16]>CCOCC>[ClH:16].[F:1][CH2:2][CH:3]([CH2:4][C:5]([OH:7])=[O:6])[NH2:8]参加物
4
実験手順
4-Fluoro-3-tert-butoxycarbonylamino-1-butanoic acid (545 mg, 2.46 mmoles) is dissolved in dry ether (20 ml) saturated with hydrogen chloride gas. After a few minutes, the solution becomes turbid and white crystals start to precipitate. Recrystallization from ethanol/ether afford beta-monofluoromethyl beta-alanine hydrochloride (265 mg, 68%), m.p. 152°-153° C. (dec).
後処理
- waitAfter a few minutes
- customto precipitate
- customRecrystallization from ethanol/ether
出典と根拠
- ORDレコード
- ord-eed7923475da4476acece2ab9d5f73eb
- 出典データセット
- uspto-grants-1983_03
- 特許番号
- US04375477
反応ノート
読み込み中…