Hydrochloric Acid → HCID 20508351、化合物
反応式
[F:1][CH:2]([F:9])[CH:3]([CH2:5][C:6]([OH:8])=[O:7])[NH2:4].[C:10](Cl)(=[O:12])[CH3:11].Cl>[OH-].[Na+].O1CCOCC1>[F:1][CH:2]([F:9])[CH:3]([NH:4][C:10](=[O:12])[CH3:11])[CH2:5][C:6]([OH:8])=[O:7]参加物
6
実験手順
To a solution of 2 mmole of beta-difluoromethyl beta-alanine in 5 ml of 1 N sodium hydroxide at 0° C. are added simultaneously from two syringes 160 mg of acetyl chloride diluted in 1 ml of dioxane and 2 ml of 1 N sodium hydroxide. After 30 minutes at 0° C. the solution is acidified by the addition of 6 N hydrochloric acid, then extracted well with dichloromethane. The organic phase is dried and concentrated to afford 3-difluoromethyl-3-(1-oxo-ethylamino) propionic acid.
後処理
- extractionextracted well with dichloromethane
- customThe organic phase is dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-14e0c993636b4027b54bdc5a80a8ffc5
- 出典データセット
- uspto-grants-1983_03
- 特許番号
- US04375477
反応ノート
読み込み中…