Ethanol → Ethyl 3-amino-4,4-difluorobutanoate hydrochloride
反応式
[F:1][CH:2]([F:9])[CH:3]([CH2:5][C:6]([OH:8])=[O:7])[NH2:4].S(Cl)([Cl:12])=O.[CH2:14](O)[CH3:15]>ClCCl>[ClH:12].[CH2:14]([O:7][C:6](=[O:8])[CH2:5][CH:3]([NH2:4])[CH:2]([F:9])[F:1])[CH3:15]参加物
5
反応条件
- 温度
- 25 °C
実験手順
A solution of 2 mmole of beta-difluoromethyl beta-alanine in 15 ml of dichloromethane is treated with 2 mmole of thionyl chloride at 25° C. for one hour after which 20 ml of ethanol is added. The solution is stirred at 25° C. for one hour and concentrated to afford 3-amino-3-difluoromethylpropionic acid ethyl ester hydrochloride.
後処理
- additionis added
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-9cef3e6946324cbabd35f3ba3eb8b3be
- 出典データセット
- uspto-grants-1983_03
- 特許番号
- US04375477
反応ノート
読み込み中…