Toluene → Ethyl 2-(1-nonen-1-yl)-3,3-dimethylcyclopropanecarboxylate

HRID 354696

反応式

HRID 354696 の反応式
C([Li])CCC.[Br-].[CH2:7]([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[CH:34]([CH:36]1[C:38]([CH3:40])([CH3:39])[CH:37]1[C:41]([O:43][CH2:44][CH3:45])=[O:42])=O.C1(C)C=CC=CC=1>CCCCCC.O1CCCC1.O>[CH:34]([CH:36]1[C:38]([CH3:40])([CH3:39])[CH:37]1[C:41]([O:43][CH2:44][CH3:45])=[O:42])=[CH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

参加物

8

反応物 4

HCID 1140TolueneHCID 566079Ethyl 3-formyl-2,2-dimethylcyclopropane-1-carboxylateHCID 3084855Octyltriphenylphosphonium bromideHCID 178418339Butyllithium

生成物 1

HCID 54188881Ethyl 2-(1-nonen-1-yl)-3,3-dimethylcyclopropanecarboxylate収率 57%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒HCID 8058Hexane溶媒

実験手順

64.5 g of a 15% strength solution of butyl-lithium in n-hexane were added dropwise to a suspension of 68.3 g (0.15 mol) of n-octyl-triphenylphosphonium bromide in 300 ml of absolute tetrahydrofuran at 0°-5° C., with the exclusion of air. After one hour, 25.5 g (0.15 mol) of ethyl 2-formyl-3,3-dimethylcyclopropanecarboxylate were slowly added, and the mixture was further stirred for 18 hours at room temperature. The mixture was shaken after the addition of 400 ml of toluene and 300 ml of water, the water was separated off and the organic phase was washed once again with 200 ml of water. The toluene solution was then dried over sodium sulphate and the solvent was distilled off in vacuo. The residue was stirred with 300 ml of petroleum ether (40°-60° C.), the solution was filtered off from the undissolved triphenylphosphine oxide, and the filtrate was again concentrated by evaporation in vacuo. The residue was distilled in vacuo. 22.6 g (57% of theory) of ethyl 2-(1-nonen-1-yl)-3,3-dimethylcyclopropanecarboxylate with a boiling point of 90° C./0.01 mm Hg were thus obtained.

後処理

  1. stirringThe mixture was shaken
  2. customthe water was separated off
  3. washthe organic phase was washed once again with 200 ml of water
  4. dry with materialThe toluene solution was then dried over sodium sulphate
  5. distillationthe solvent was distilled off in vacuo
  6. stirringThe residue was stirred with 300 ml of petroleum ether (40°-60° C.)
  7. filtrationthe solution was filtered off from the undissolved triphenylphosphine oxide
  8. concentrationthe filtrate was again concentrated by evaporation in vacuo
  9. distillationThe residue was distilled in vacuo

出典と根拠

ORDレコード
ord-180eb195a3fc49f1b48ad354030375a7
出典データセット
uspto-grants-1983_03
特許番号
US04376786

関連ノート

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