3,4-Dimethoxy-2-nitrobenzoic acid → 2-Amino-3,4-dimethoxybenzoic acid
反応式
[CH3:1][O:2][C:3]1[C:4]([N+:14]([O-])=O)=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([OH:8])=[O:7].[H][H]>[OH-].[NH4+].[Pd]>[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:5]([C:6]([OH:8])=[O:7])[C:4]=1[NH2:14]参加物
5
実験手順
A solution of 3,4-dimethoxy-2-nitro benzoic acid (1011 g., 4.45 moles) in 14 liters of 1.3 N ammonium hydroxide was reduced at 60 psi in presence of 60 grams of palladium on barium carbonate. Hydrogen uptake ceased after four hours. The reaction mixture was filtered through diatomaceous earth and acidified with glacial acetic acid (1.2 liters) to yield 685 grams (78%) of the anthranilic acid, M.P. 183°-184° C.
後処理
- filtrationThe reaction mixture was filtered through diatomaceous earth
出典と根拠
- ORDレコード
- ord-9f9306c19b6b4f69a7f9343fbd0387ff
- 出典データセット
- uspto-grants-1983_03
- 特許番号
- US04377581
反応ノート
読み込み中…