Dimethylformamide → Dimethyl[{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate

HRID 354876

反応式

HRID 354876 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:12][C:13](=[O:19])[CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH:10]=2)[N:5]=[CH:4][N:3]=1.CO[CH:22]=[C:23]([C:28]([O:30][CH3:31])=[O:29])[C:24]([O:26][CH3:27])=[O:25].CN(C)C=O>O>[CH3:17][C:15]([CH3:16])([CH3:18])[CH2:14][C:13]([NH:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:1][CH:22]=[C:23]([C:28]([O:30][CH3:31])=[O:29])[C:24]([O:26][CH3:27])=[O:25])=[O:19]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 90770Dimethyl methoxymethylenemalonateHCID 130604604-Amino-6-(3,3-dimethylbutyramido)quinazoline

生成物 1

HCID 13060506Dimethyl[{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate収率 82.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4-amino-6-(3,3-dimethylbutyramido)quinazoline (8.5 g), dimethyl methoxymethylenepropanedioate (12.75 g) and N,N-dimethylformamide (34 g) was stirred for an hour at 100° C. After cooling to ambient temperature, to the resultant mixture was added water to give precipitates, which were separated by filtration, washed with water and dried to give crystalline dimethyl [{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate (10.9 g).

後処理

  1. customto give
  2. customprecipitates
  3. customwhich were separated by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-6f04d01d001e42d49a57e812aa48595c
出典データセット
uspto-grants-1983_03
特許番号
US04377580

関連ノート

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