Water → Sulbactam

HRID 354916

反応式

HRID 354916 の反応式
[CH3:1][C:2]1([CH3:15])[S:6](=[O:8])(=[O:7])[CH:5]2[CH2:9][C:10](=[O:11])[N:4]2[CH:3]1[C:12]([O-:14])=[O:13].[Na+].O.C(=O)(O)[O-].[Na+].S([O-])([O-])(=O)=O.[Na+].[Na+]>S(=O)(=O)(O)[O-].C([N+](CCCC)(CCCC)CCCC)CCC.C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:15])[S:6](=[O:7])(=[O:8])[C@@H:5]2[CH2:9][C:10](=[O:11])[N:4]2[C@H:3]1[C:12]([OH:14])=[O:13]

参加物

7

反応物 4

HCID 962WaterHCID 24436Sodium SulfateHCID 516892Sodium BicarbonateHCID 23691718Sodium penicillanate 1,1-dioxide

生成物 1

HCID 130313Sulbactam

試薬・触媒・溶媒 2

HCID 94433Tetrabutylammonium hydrogen sulfate触媒HCID 6212Chloroform溶媒

実験手順

To a stirred solution of 2.55 g. of sodium penicillanate 1,1-dioxide in 20 ml. of water was added 3.80 g. of tetrabutylammonium bisulfate. Stirring was continued for 5 minutes and then 20 ml. of chloroform was added. The pH was adjusted to 6.8 with saturated aqueous sodium bicarbonate and then the aqueous layer was saturated with sodium sulfate. The layers were separated and the aqueous layer was extracted with chloroform. The combined chloroform solutions were dried using sodium sulfate and then evaporated in vacuo to give the tetrabutylammonium salt of penicillanic acid 1,1-dioxide.

後処理

  1. customThe layers were separated
  2. extractionthe aqueous layer was extracted with chloroform
  3. dry with materialThe combined chloroform solutions were dried
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-ac2e53e3cddb465cb06bb2f8c3814586
出典データセット
uspto-grants-1983_03
特許番号
US04377590

関連ノート

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