1-Bromo-3-chloropropane → 1-(3-chloropropyl)-2-phenyl-1H-benzimidazole

HRID 354928

反応式

HRID 354928 の反応式
[C:1]1([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O-].[Na+].Br[CH2:20][CH2:21][CH2:22][Cl:23]>CC(O)C>[Cl:23][CH2:22][CH2:21][CH2:20][N:11]1[C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[N:8]=[C:7]1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 80061-Bromo-3-chloropropaneHCID 128552-PhenylbenzimidazoleHCID 10942334Sodium Methoxide

生成物 1

HCID 205062561-(3-chloropropyl)-2-phenyl-1H-benzimidazole

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
50 °C

実験手順

A mixture of 38.8 parts of 2-phenyl-1H-benzimidazole, 44 parts of a sodium methoxide solution 30% and 320 parts of 2-propanol is stirred and heated for 15 minutes at 50° C. After cooling, there are added 47.25 parts of 1-bromo-3-chloropropane. The whole is stirred and refluxed for 3 hours. The reaction mixture is evaporated. The residue is diluted with water and the product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 1-(3-chloropropyl)-2-phenyl-1H-benzimidazole as a residue.

後処理

  1. temperatureAfter cooling
  2. stirringThe whole is stirred
  3. temperaturerefluxed for 3 hours
  4. customThe reaction mixture is evaporated
  5. additionThe residue is diluted with water
  6. extractionthe product is extracted with methylbenzene
  7. customThe extract is dried
  8. filtrationfiltered
  9. customevaporated

出典と根拠

ORDレコード
ord-839dba5ff7384a6fa41039c5aee44343
出典データセット
uspto-grants-1983_03
特許番号
US04377578

関連ノート

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