関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 反応物 | 2-Phenylbenzimidazole | HCID 12855 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1-(3-chloropropyl)-2-phenyl-1H-benzimidazole | HCID 20506256 | — |
反応手順
A mixture of 38.8 parts of 2-phenyl-1H-benzimidazole, 44 parts of a sodium methoxide solution 30% and 320 parts of 2-propanol is stirred and heated for 15 minutes at 50° C. After cooling, there are added 47.25 parts of 1-bromo-3-chloropropane. The whole is stirred and refluxed for 3 hours. The reaction mixture is evaporated. The residue is diluted with water and the product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 1-(3-chloropropyl)-2-phenyl-1H-benzimidazole as a residue.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04377578 |
|---|
| 出典データセット | uspto-grants-1983_03 |
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| ORD ID | ord-839dba5ff7384a6fa41039c5aee44343 |
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| 出典メモ | uspto-grants-1983_03 |
|---|
