反应详情

温度

50 °C

A mixture of 38.8 parts of 2-phenyl-1H-benzimidazole, 44 parts of a sodium methoxide solution 30% and 320 parts of 2-propanol is stirred and heated for 15 minutes at 50° C. After cooling, there are added 47.25 parts of 1-bromo-3-chloropropane. The whole is stirred and refluxed for 3 hours. The reaction mixture is evaporated. The residue is diluted with water and the product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 1-(3-chloropropyl)-2-phenyl-1H-benzimidazole as a residue.

1. temperatureAfter cooling
2. stirringThe whole is stirred
3. temperaturerefluxed for 3 hours
4. customThe reaction mixture is evaporated
5. additionThe residue is diluted with water
6. extractionthe product is extracted with methylbenzene
7. customThe extract is dried
8. filtrationfiltered
9. customevaporated