Hydrochloric Acid → HCID 57177388、化合物

HRID 355131

反応式

HRID 355131 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:15]1[CH2:20][CH2:19][CH:18]=[CH:17][CH2:16]1.Cl>O>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:15]2[CH2:20][CH2:19][CH:18]=[CH:17][CH2:16]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 127501,2,3,6-TetrahydropyridineHCID 67306Benzoic acid, 2-chloro-5-(chlorosulfonyl)-

生成物 1

HCID 57177388HCID 57177388、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Chloro-5-chlorosulfonylbenzoic acid (25.5 g.) is added in small portions over a 5 minute period with cooling to a solution of 1,2,5,6-tetrahydropyridine (25.0 g.) in 200 ml. of water. After stirring at room temperature for a half hour, the reaction mixture is acidified with concentrated hydrochloric acid. The crystalline precipitate is filtered off and dissolved in 75 ml. of methylene chloride and 10 ml. of ether. After concentration to 50 ml., hexane is added to turbidity, affording crystals, m.p. 180°-182° C.

後処理

  1. filtrationThe crystalline precipitate is filtered off
  2. dissolutiondissolved in 75 ml
  3. concentrationAfter concentration to 50 ml
  4. addition, hexane is added to turbidity
  5. customaffording crystals, m.p. 180°-182° C.

出典と根拠

ORDレコード
ord-e1cc92d96e384ebd9f14ddf9ddf568af
出典データセット
uspto-grants-1983_03
特許番号
US04377521

関連ノート

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