Thionyl Chloride → HCID 20505854、化合物

反応式

[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH:18]([CH3:20])[CH2:17][CH:16]([CH3:21])[CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:24])=O>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH:18]([CH3:20])[CH2:17][CH:16]([CH3:21])[CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([Cl:24])=[O:5]

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 30158922-Chloro-5-(3,5-dimethylpiperidinosulphonyl)benzoic acid

生成物 1

HCID 20505854HCID 20505854、化合物

実験手順

2-Chloro-5-(3,5-dimethylpiperidinosulfonyl)benzoic acid (6.0 g.) is refluxed for 21/2 hours with 50 ml. of thionyl chloride, and then taken to dryness. The residue is triturated with 200 ml. of hot benzene-hexane (1:1), filtered and evaporated to obtain the dry product, m.p. 164°-166.5° C.

後処理

customThe residue is triturated with 200 ml
filtrationof hot benzene-hexane (1:1), filtered
customevaporated
customto obtain the dry product, m.p. 164°-166.5° C.

出典と根拠

ORDレコード: ord-da079bc7c92b49e09f3aec476ce215b3
出典データセット: uspto-grants-1983_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04377521

反応ノート

読み込み中…

参加物