Benzoyl chloride → 3-(Phenylformamido)butanoic acid
反応式
[NH2:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].[C:8](Cl)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>[OH-].[Na+]>[C:8]([NH:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1参加物
4
実験手順
To a cooled solution of 3-aminobutyric acid (13 g) in 2M NaOH (130 ml) is added benzoyl chloride (19.7 g) over the course of two hours. The mixture is allowed to warm to room temperature. Washing with diethyl ether, acidifying of the aqueous phase with 20% HCI, extraction with diethyl ether, drying over MgSO4, evaporation of the solvent and recrystallization in ether/hexane gives the title compound m.p. 150°-152° C. (compound 1.16, Table 1).
後処理
- washWashing with diethyl ether, acidifying of the aqueous phase with 20% HCI, extraction with diethyl ether
- dry with materialdrying over MgSO4, evaporation of the solvent and recrystallization in ether/hexane
出典と根拠
- ORDレコード
- ord-537ccc3806ee401eacc4b26539a26b88
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05830919
反応ノート
読み込み中…