Tris(hydroxymethyl)aminomethane → N,N'-bis-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-L-tartaramide

HRID 355473

反応式

HRID 355473 の反応式
[C:1]([C@@H:5]([C@H:7]([C:9]([O:11]C)=O)[OH:8])[OH:6])([O:3]C)=O.[OH:13][CH2:14][C:15]([CH2:19][OH:20])([CH2:17][OH:18])[NH2:16]>CO>[OH:13][CH2:14][C:15]([NH:16][C:1](=[O:3])[C@@H:5]([C@H:7]([C:9]([NH:16][C:15]([CH2:19][OH:20])([CH2:17][OH:18])[CH2:14][OH:13])=[O:11])[OH:8])[OH:6])([CH2:19][OH:20])[CH2:17][OH:18]

参加物

4

反応物 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 11851Dimethyl L-tartrate

生成物 1

HCID 54556382N,N'-bis-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-L-tartaramide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A suspension of 1.78 g of dimethyl L-tartrate and 4.85 g of tris-hydroxymethyl-methylamine in 50 ml of methanol was heated under reflux for 6 days and then concentrated. The residue was purified by chromatography over silica gel with ethyl acetate/methanol/water as the eluent and gave N,N'-bis-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-L-tartaramide, [a]+101.00 (c 0.4; dimethyl sulfoxide), MS: m/z 357.3 ([M+H]+).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 6 days
  3. concentrationconcentrated
  4. customThe residue was purified by chromatography over silica gel with ethyl acetate/methanol/water as the eluent

出典と根拠

ORDレコード
ord-26e82b218d7c4c3f984d97f4e457a6e5
出典データセット
uspto-grants-1998_11
特許番号
US05830920

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