Propylene Oxide → 2-Hydroxypropyl-Beta-Cyclodextrin

HRID 355500

反応式

HRID 355500 の反応式
[CH2:1]([OH:77])[C@H:2]1[O:7][C@@H:6]2[O:8][C@H:9]3[C@H:14]([OH:15])[C@@H:13]([OH:16])[C@@H:12]([O:17][C@H:18]4[C@H:23]([OH:24])[C@@H:22]([OH:25])[C@@H:21]([O:26][C@H:27]5[C@H:32]([OH:33])[C@@H:31]([OH:34])[C@@H:30]([O:35][C@H:36]6[C@H:41]([OH:42])[C@@H:40]([OH:43])[C@@H:39]([O:44][C@H:45]7[C@H:50]([OH:51])[C@@H:49]([OH:52])[C@@H:48]([O:53][C@H:54]8[C@H:60]([OH:61])[C@@H:59]([OH:62])[C@@H:57]([O:58][C@H:3]1[C@H:4]([OH:76])[C@H:5]2[OH:75])[O:56][C@@H:55]8[CH2:63][OH:64])[O:47][C@@H:46]7[CH2:65][OH:66])[O:38][C@@H:37]6[CH2:67][OH:68])[O:29][C@@H:28]5[CH2:69][OH:70])[O:20][C@@H:19]4[CH2:71][OH:72])[O:11][C@@H:10]3[CH2:73][OH:74].[CH2:78]1[O:81][CH:79]1[CH3:80]>[OH-].[Na+]>[CH3:3][CH:2]([OH:7])[CH2:1][O:70][CH2:69][C@H:28]1[O:29][C@@H:30]2[O:35][C@H:36]3[C@H:41]([OH:42])[C@@H:40]([OH:43])[C@@H:39]([O:44][C@H:45]4[C@H:50]([OH:51])[C@@H:49]([OH:52])[C@@H:48]([O:53][C@H:54]5[C@H:60]([OH:61])[C@@H:59]([OH:62])[C@@H:57]([O:58][C@H:3]6[C@H:4]([OH:76])[C@@H:5]([OH:75])[C@@H:6]([O:8][C@H:9]7[C@H:14]([OH:15])[C@@H:13]([OH:16])[C@@H:12]([O:17][C@H:18]8[C@H:23]([OH:24])[C@@H:22]([OH:25])[C@@H:21]([O:26][C@H:27]1[C@H:32]([OH:33])[C@H:31]2[OH:34])[O:20][C@@H:19]8[CH2:71][O:72][CH2:41][CH:36]([OH:35])[CH3:37])[O:11][C@@H:10]7[CH2:73][O:74][CH2:14][CH:9]([OH:8])[CH3:10])[O:7][C@@H:2]6[CH2:1][O:77][CH2:28][CH:27]([OH:26])[CH3:32])[O:56][C@@H:55]5[CH2:63][O:64][CH2:46][CH:45]([OH:44])[CH3:50])[O:47][C@@H:46]4[CH2:65][O:66][CH2:19][CH:18]([OH:17])[CH3:23])[O:38][C@@H:37]3[CH2:67][O:68][CH2:78][CH:79]([OH:81])[CH3:80]

参加物

4

反応物 2

HCID 6378Propylene OxideHCID 444041beta-Cyclodextrin

生成物 1

HCID 140496892-Hydroxypropyl-Beta-Cyclodextrin収率 90%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

In HU 202889, β-cyclodextrin (β-CD) is reacted with propylene oxide in aqueous sodium hydroxide solution to give hydroxypropyl-β-cyclodextrin. The resulting sodium chloride and the propylene glycol are removed by ion exchange and precipitation of the hydroxypropylated β-cyclodextrin in large amounts of acetone, filtration, taking up the filter cake in water, distillation and, finally, spray-drying. The yield is around 90%, and the salt and propylene glycol content is 0.1%.

出典と根拠

ORDレコード
ord-c36e3932b4f34fda91e3be6ef927cbeb
出典データセット
uspto-grants-1998_11
特許番号
US05831081

関連ノート

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