関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Boc-Tyr(OBn)-Ser(OBn)-CO2Me | HCID 131720919 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Tyr(OBn)-Ser(OBn)-CO2Me.TFA | HCID 131720922 | — |
反応手順
Boc-Tyr(OBn)-Ser(OBn)-CO2Me (from Step 1 above, 2.64 g, 4.69 mmol) was dissolved in CH2Cl2 (15 mL), cooled to 0° C. and TFA (5 mL) was added. The solution was warmed to room temperature and stirred for 4 hours. The solution was concentrated, taken up in CH2Cl2 and reconcentrated twice. The resulting oil was triturated with ether to provide 2.7 g of the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05830868 |
|---|
| 出典データセット | uspto-grants-1998_11 |
|---|
| ORD ID | ord-1be268c7d80f41fd84f72c94707aaa4e |
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| 出典メモ | uspto-grants-1998_11 |
|---|
