ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Dimethylformamide → HCID 22116938、化合物

HRID 355594
ノート
印刷プレビュー

反応式

HRID 355594 の反応式
[CH3:1][C:2]1([CH3:26])[C:6](=[O:7])[N:5]([C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:9]=2)[C:4](=[O:20])[N:3]1[CH2:21][CH2:22][CH2:23][CH2:24][OH:25].[C:27](Cl)([C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.C(N(CC)CC)C.CN(C)C=O>CN(C)C1C=CN=CC=1.CCOCC.O>[O:20]=[C:4]1[N:3]([CH2:21][CH2:22][CH2:23][CH2:24][O:25][C:27]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:2]([CH3:26])([CH3:1])[C:6](=[O:7])[N:5]1[C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[C:10]([C:16]([F:17])([F:18])[F:19])[CH:9]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

8

反応物 4

HCID 6228DimethylformamideHCID 6456Trityl chlorideHCID 8471TriethylamineHCID 1329814-(3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile

生成物 1

HCID 22116938HCID 22116938、化合物収率 76.2%

試薬・触媒・溶媒 3

HCID 14284
4-(Dimethylamino)pyridine
触媒
HCID 962Water溶媒
HCID 3283Diethyl Ether溶媒

反応条件

温度
40 °C

実験手順

370 mg of the product of Example 58, 307 mg of trityl chloride in the presence of 10 mg of 4-dimethylaminopyridine, 0.25 ml of triethylamine and 4 ml of dimethylformamide were stirred at ambient temperature for 16 hours. The mixture was heated to 40° C. for 4 hours, poured into water and extraction was carried out with ether. The extracts were washed with water and dried and the solvent was eliminated under reduced pressure. The residue was chromatographed on silica (eluant: cyclohexane--ethyl acetate 75-25) to obtain 467 mg of the expected product with a Rf=0.25.

後処理

  1. washThe extracts were washed with water
  2. customdried
  3. customThe residue was chromatographed on silica (eluant: cyclohexane--ethyl acetate 75-25)

出典と根拠

ORDレコード
ord-5e1f7b717f3749b6b581c38ca2984e61
出典データセット
uspto-grants-1998_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
USRE035956

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート