Nitric Acid → HCID 13037332、化合物

HRID 355823

反応式

HRID 355823 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2].[N+:19]([O-])([OH:21])=[O:20]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][C:14]([N+:19]([O-:21])=[O:20])=[CH:13][CH:12]=3)=[O:5])[CH3:2]

参加物

3

反応物 2

HCID 944Nitric AcidHCID 105078Ethyl Beta-Carboline-3-Carboxylate

生成物 1

HCID 13037332HCID 13037332、化合物収率 63%

実験手順

9H-β-carboline-3-carboxylic acid ethyl ester (20 g, 833 mmol) was slowly added to concentrated nitric acid (400 mL). The reaction mixture was stirred at 70°-75° C. for 2 h. After cooling to room temperature the resulting mixture was poured onto ice (1 kg). The precipitated compound was collected, and recrystallized from pyridine (650 mL). This afforded the title compound (14.9 g, 63%). M.p. 339°-341° C.

後処理

  1. additionwas poured onto ice (1 kg)
  2. customThe precipitated compound was collected
  3. customrecrystallized from pyridine (650 mL)

出典と根拠

ORDレコード
ord-bde2ebc93c234b76abec48393aeae3d3
出典データセット
uspto-grants-1998_11
特許番号
US05834482

関連ノート

読み込み中…