Sulfuric acid magnesium salt (1:1) → 8-Acetylamino-5,6-difluoro-1-tetralone

HRID 355974ノート

反応式

HRID 355974 の反応式
[C:1]([NH:4][C:5]1[CH:14]=[C:13]([F:15])[C:12]([F:16])=[C:11]2[C:6]=1[CH2:7][CH2:8][CH2:9][CH2:10]2)(=[O:3])[CH3:2].S([O-])([O-])(=O)=[O:18].[Mg+2].[Mn]([O-])(=O)(=O)=O.[K+]>CC(C)=O>[C:1]([NH:4][C:5]1[CH:14]=[C:13]([F:15])[C:12]([F:16])=[C:11]2[C:6]=1[C:7](=[O:18])[CH2:8][CH2:9][CH2:10]2)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 516875Potassium PermanganateHCID 10609230HCID 10609230、化合物

生成物 1

HCID 224495258-Acetylamino-5,6-difluoro-1-tetralone

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of the compound obtained in (6) above (810 mg) in 30 ml of acetone was added 3 ml of 15% aqueous solution of magnesium sulfate. 1.17 gm of potassium permanganate was slowly added to the mixture while stirring. After 1 hour, the reaction product was extracted with chloroform, the extract was washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated to obtain 806 mg of the title compound.

後処理

  1. extractionthe reaction product was extracted with chloroform
  2. washthe extract was washed with water and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-7efb3e174d354fc8a73c694376b643dd
出典データセット
uspto-grants-1998_11
特許番号
US05834476

反応ノート

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