1,4-Dibromobutane → 3-(2-Pyrrolidin-1-ylethyl)anisole

HRID 35600

反応式

HRID 35600 の反応式
C(=O)([O-])[O-].[Na+].[Na+].[CH3:7][O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=1.Br[CH2:19][CH2:20][CH2:21][CH2:22]Br>C1(C)C(C)=CC=CC=1>[N:17]1([CH2:16][CH2:15][C:11]2[CH:10]=[C:9]([O:8][CH3:7])[CH:14]=[CH:13][CH:12]=2)[CH2:22][CH2:21][CH2:20][CH2:19]1

参加物

5

反応物 3

HCID 80561,4-DibromobutaneHCID 10340Sodium CarbonateHCID 748663-Methoxyphenethylamine

生成物 1

HCID 183650073-(2-Pyrrolidin-1-ylethyl)anisole

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A stirred suspension of anhydrous sodium carbonate (0.923 g), 2-(3-methoxyphenyl)ethylamine (0.5 g) and 1,4-dibromobutane (0.43 ml) in dry xylene (5.5 ml) was heated under reflux for 16 hours. The reaction mixture was allowed to cool to room temperature and was filtered. The filtrate was extracted with 5N hydrochloric acid. The acidic extracts were washed with ether and then basified with 5N sodium hydroxide solution and extracted with ether. The ether extracts were washed with water, dried and the ether removed by evaporation to give 3-(2-pyrrolidin-1-ylethyl)anisole.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. filtrationwas filtered
  4. extractionThe filtrate was extracted with 5N hydrochloric acid
  5. washThe acidic extracts were washed with ether
  6. extractionextracted with ether
  7. washThe ether extracts were washed with water
  8. customdried
  9. customthe ether removed by evaporation

出典と根拠

ORDレコード
ord-dc7075a1af0549cfa7884368ccc5eb71
出典データセット
uspto-grants-1988_08
特許番号
US04767769

関連ノート

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