Isopropanol → 6-Isopropoxy-2-methylamino-3-nitropyridine
反応式
Cl[C:2]1[N:7]=[C:6]([NH:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][CH:3]=1.[H-].[Na+].[CH:15]([OH:18])([CH3:17])[CH3:16]>CN(C)C=O>[CH:15]([O:18][C:2]1[N:7]=[C:6]([NH:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][CH:3]=1)([CH3:17])[CH3:16]参加物
5
実験手順
A procedure similar to that described in Preparation 88 was repeated, except that 6.00 g of 6-chloro-2-methylamino-3-nitropyridine (prepared as described in Preparation 66), 1.54 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 2.7 ml of isopropanol and 150 ml of dimethylformamide were used. After working up the product as described in Preparation 88, the resulting crude product was crystallized by trituration with isopropanol, to give 6.10 g of the title compound, melting at 75°-76° C.
後処理
- customA procedure similar to that described in Preparation 88
- customas described in Preparation 88
- customthe resulting crude product was crystallized by trituration with isopropanol
出典と根拠
- ORDレコード
- ord-d8ceae9cc8f94078abb8e47ffdf0be3b
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05834501
反応ノート
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