Sodium Hydroxide → 2-Chloro-1,3-thiazole-4-carboxylic acid

HRID 356440ノート

反応式

HRID 356440 の反応式
[OH-].[Na+].C([O:5][C:6]([C:8]1[N:9]=[C:10]([Cl:13])[S:11][CH:12]=1)=[O:7])C>C(O)C>[Cl:13][C:10]1[S:11][CH:12]=[C:8]([C:6]([OH:7])=[O:5])[N:9]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 13106141Ethyl 2-chlorothiazole-4-carboxylate

生成物 1

HCID 218030262-Chloro-1,3-thiazole-4-carboxylic acid収率 61.1%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of NaOH (1.9 g, 47.5 mmol) and ethyl-2-chloro-4-thiazolecarboxylate (7.6 g, 40 mmol) in 100 mL absolute ethanol was stirred at RT for 4 h. After that, ethanol was removed in vacuo and the residue was dissolved in water. The aq layer was washed with ether and then acidified with conc HCl. The solid was filtered and air dried to give 4 g of 2-chloro-4-thiazolecarboxylic acid.

後処理

  1. customAfter that, ethanol was removed in vacuo
  2. dissolutionthe residue was dissolved in water
  3. washThe aq layer was washed with ether
  4. filtrationThe solid was filtered
  5. customair dried

出典と根拠

ORDレコード
ord-a8762a94cad2465db75febb4a7a983fd
出典データセット
uspto-grants-1998_11
特許番号
US05834447

反応ノート

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