Oxalyl chloride → 3-(4-Nitrophenyl)propionyl chloride
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([OH:14])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].C(Cl)(=O)C([Cl:18])=O>C(Cl)Cl.CN(C=O)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([Cl:18])=[O:14])=[CH:6][CH:5]=1)([O-:3])=[O:2]参加物
5
実験手順
3-(4-Nitrophenyl)propanoic acid prepared in Example DD (12.5 g, 64 mmol) was suspended in CH2Cl2 (300 mL) and treated with oxalyl chloride (7.4 mL, 85 mmol) and DMF (5 drops). The solution was stirred overnight at room temperature. The solution was concentrated, and the residue was dissolved in CH2Cl2 and re-concentrated. The crude product was used as is in the next step.
後処理
- concentrationThe solution was concentrated
- dissolutionthe residue was dissolved in CH2Cl2
- concentrationre-concentrated
出典と根拠
- ORDレコード
- ord-9d995b24aa6f4bc1bc16cc3926527678
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05834506
反応ノート
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