HCID 44323914、化合物 → 4-(5-Phenyl-4-pyridin-4-yl-1H-pyrrol-2-yl)-phenylamine

HRID 356691ノート

反応式

HRID 356691 の反応式
[C:1]1([C:7]2[NH:8][C:9]([C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=3)=[CH:10][C:11]=2[C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(OCC)(=O)C.C(O)C.[Pt](=O)=O>[C:1]1([C:7]2[NH:8][C:9]([C:18]3[CH:19]=[CH:20][C:21]([NH2:24])=[CH:22][CH:23]=3)=[CH:10][C:11]=2[C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 1

HCID 44323914HCID 44323914、化合物

生成物 1

HCID 443237254-(5-Phenyl-4-pyridin-4-yl-1H-pyrrol-2-yl)-phenylamine

試薬・触媒・溶媒 3

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a suspension of 55 mg (0.161 mmol) 2-phenyl-3-(4-pyridyl)-5-[(4-nitro)phenyl]-1H-pyrrole (prepared according to Example 33) in 1.5 ml ethyl acetate and 1.5 ml ethanol was added 10 mg platinum (IV) oxide. The mixture was stirred under H2 for 2 hours. The contents of flask were centrifuged, and the catalyst washed with ethyl acetate three times. The solvents were evaporated in vacuo to afford the desired product as a pale orange solid, homogeneous by TLC (5% MeOH/CH2Cl2). FAB ms: Calc.: 312 for C21H17N3 ; Obs.: 313 (M+ +1).

後処理

  1. customThe contents of flask were centrifuged
  2. washthe catalyst washed with ethyl acetate three times
  3. customThe solvents were evaporated in vacuo

出典と根拠

ORDレコード
ord-664f03b5ec104283b98ab1b6832dc70a
出典データセット
uspto-grants-1998_11
特許番号
US05837719

反応ノート

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