Oxalyl chloride → 5-Carboethoxythiophen-2-carbonyl chloride
反応式
[C:1]([C:6]1[S:10][C:9]([C:11]([OH:13])=O)=[CH:8][CH:7]=1)([O:3][CH2:4][CH3:5])=[O:2].C(Cl)(C([Cl:18])=O)=O>ClCCl.CN(C=O)C>[C:1]([C:6]1[S:10][C:9]([C:11]([Cl:18])=[O:13])=[CH:8][CH:7]=1)([O:3][CH2:4][CH3:5])=[O:2]参加物
5
実験手順
To a suspension of acid 35 (0.64 g, 3.2 mmol) in dichloromethane (20 mL) under argon at room temperature was added a 2.0M solution of (COCl)2 in dichloromethane (2.4 mL, 4.8 mmol) and two drops of DMF, and stirred overnight. Excess (COCl)2 and dichloromethane were removed at reduced pressure, and the viscous, light, yellow product was dried overnight to afford the desired benzoyl chloride 36 as a yellow solid. The structure of the product was also confirmed using IR and 1H NMR spectroscopy.
後処理
- customExcess (COCl)2 and dichloromethane were removed at reduced pressure
- customthe viscous, light, yellow product was dried overnight
出典と根拠
- ORDレコード
- ord-e97b5a575fb346c99bba8ebb8b03ff6e
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05837725
反応ノート
読み込み中…