6-Nitro-4-oxo-1-propionyl1,2,3,4-tetrahydroquinoline → 6-Amino-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline
反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]([C:14](=[O:17])[CH2:15][CH3:16])[CH2:9][CH2:8][C:7]2=[O:18])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]([C:14](=[O:17])[CH2:15][CH3:16])[CH2:9][CH2:8][C:7]2=[O:18]参加物
4
実験手順
A solution of 6-nitro-4-oxo-1-propionyl1,2,3,4-tetrahydroquinoline (6.076 g) in methanol (60 ml) was hydrogenated over 5% palladium on carbon (0.5 g) under atmospheric pressure at ambient temperature. After the theoretical amount of hydrogen gas was absorbed, the catalyst was filtered off and the filtrate was evaporated in vacuo. The residual solid was washed with diethyl ether and dried to give 6amino-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (4.815 g).
後処理
- customAfter the theoretical amount of hydrogen gas was absorbed
- filtrationthe catalyst was filtered off
- customthe filtrate was evaporated in vacuo
- washThe residual solid was washed with diethyl ether
- customdried
出典と根拠
- ORDレコード
- ord-0af32720cf964cb6b5c302da4faf5314
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04767780
反応ノート
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