Methyl 4-(methylsulfanyl)-3-nitrobenzenecarboxylate → Methyl 3-amino-4-(methylthio)benzoate
反応式
[CH3:1][S:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:4]=1[N+:13]([O-])=O>CO.[Pd]>[NH2:13][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:3]=1[S:2][CH3:1])[C:7]([O:9][CH3:10])=[O:8]参加物
4
実験手順
A stirred solution of methyl 4-methylthio-3-nitrobenzoate (6.82 g; that is prepared as described in Reference Example 51) in methanol (350 mL) is hydrogenated using a 5% wlw palladium on charcoal catalyst (0.8 g) at room temperature for 48 hours. After filtration the solution is concentrated, to give methyl 3-amino-4-(methylthio)benzoate (3.5 g), in the form of a pale yellow solid, m.p. 63°-65° C.
後処理
- customthat is prepared
- customat room temperature
- customfor 48 hours
- filtrationAfter filtration the solution
- concentrationis concentrated
出典と根拠
- ORDレコード
- ord-cf7a139a7d294067b432194511a15b8b
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05840724
反応ノート
読み込み中…