Water → 3-Isopropoxy-4-methoxybenzaldehyde

HRID 356974

反応式

HRID 356974 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH:5]=[O:6].C(=O)([O-])[O-].[K+].[K+].Br[CH:19]([CH3:21])[CH3:20].O>CN(C)C=O>[CH3:11][O:10][C:9]1[CH:8]=[CH:7][C:4]([CH:5]=[O:6])=[CH:3][C:2]=1[O:1][CH:19]([CH3:21])[CH3:20]

参加物

6

反応物 4

HCID 962WaterHCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 12127Isovanillin

生成物 1

HCID 5920923-Isopropoxy-4-methoxybenzaldehyde

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 3-hydroxy-4-methoxybenzaldehyde (20.0 g), anhydrous potassium carbonate (26.2 g) and 2-bromopropane (18.3 mL) in dry dimethylformamide (300 mL) is stirred and heated at 55°-65° C. for 24 hours. The cooled mixture is poured into water and extracted with ethyl acetate. The extract is dried over magnesium sulfate and concentrated in vacuo at 40° C., to give 4-methoxy-3-prop-2-yloxybenzaldehyde, in the form of an oil (24.2 g).

後処理

  1. temperatureheated at 55°-65° C. for 24 hours
  2. extractionextracted with ethyl acetate
  3. dry with materialThe extract is dried over magnesium sulfate
  4. concentrationconcentrated in vacuo at 40° C.

出典と根拠

ORDレコード
ord-9eb09239ec3e490088c7d9619b869569
出典データセット
uspto-grants-1998_11
特許番号
US05840724

関連ノート

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