Pyridine → HCID 18936915、化合物

反応式

[C:1]([O:4][C:5](=[O:7])[CH3:6])(=O)[CH3:2].OC1[C:10]([C:19]([NH2:21])=[O:20])=[CH:11][C:12]2[C:17](C=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.N1C=CC=CC=1>>[C:5]([O:4][C:1]1[C:10]([C:19]([NH2:21])=[O:20])=[CH:11][C:12]2[C:17]([CH:2]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:7])[CH3:6]

参加物

反応物 3

HCID 1049Pyridine

HCID 7918Acetic Anhydride

HCID 193173-Hydroxy-2-naphthalenecarboxamide

生成物 1

HCID 18936915HCID 18936915、化合物

実験手順

Acetic anhydride (19.2 ml, 200 mmol) was added to a solution of 18 (29.95 g, 160 mmol) in pyridine (32 ml, 400 mmol) and the mixture was maintained at room temperature for 30 minutes. The solid was filtered off, washed with acetone and dried (MgSO4), generating 27.06 g (74%) of 19 as pale yellow crystals, mp 201°-202° C. (lit. 203°-205° C.).

後処理

filtrationThe solid was filtered off
washwashed with acetone
dry with materialdried (MgSO4)
custom27.06 g (74%) of 19 as pale yellow crystals, mp 201°-202° C. (lit. 203°-205° C.)

出典と根拠

ORDレコード: ord-e1a40066d05841c2807e5b2bbd80f3ae
出典データセット: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05840739

反応ノート

読み込み中…

参加物