Sodium Iodide → 3-[4-(2-Aminopyridin-3-yloxy)butyl]thiazolidine-2,4-dione

反応式

[NH2:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12]Cl)=[CH:6][CH:5]=[CH:4][N:3]=1.[Na].[S:15]1[CH2:19][C:18](=[O:20])[NH:17][C:16]1=[O:21].[I-].[Na+]>>[NH2:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][N:17]2[C:18](=[O:20])[CH2:19][S:15][C:16]2=[O:21])=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

反応物 3

HCID 5238Sodium Iodide

HCID 189367812-Amino-3-(4-chlorobutyloxy)pyridine

HCID 867387272,4-Thiazolidinedione sodium salt

生成物 1

HCID 189367033-[4-(2-Aminopyridin-3-yloxy)butyl]thiazolidine-2,4-dione

実験手順

Using 10.06 g (50 mmol) of 2-amino-3-(4-chlorobutyloxy)pyridine, 6.97 g (50 mmol) of thiazolidine-2,4-dione sodium salt and 7.49 g (50 mmol) of sodium iodide, the same procedure as in Reference Example 11 was followed, to yield 9.53 g (67.8%, light yellow oily substance) of the desired product.

出典と根拠

ORDレコード: ord-1df695eb32874ee8a019d3cfd6b0fba8
出典データセット: uspto-grants-1998_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05840732

反応ノート

読み込み中…