反応式
[OH:1][C:2]([CH3:8])([CH3:7])[C:3]([O:5][CH3:6])=[O:4].N1C=CN=C1.[CH3:14][Si:15](Cl)([CH3:17])[CH3:16]>C(Cl)Cl>[CH3:14][Si:15]([CH3:17])([CH3:16])[O:1][C:2]([CH3:8])([CH3:7])[C:3]([O:5][CH3:6])=[O:4]参加物
5
実験手順
To a solution of 1.2 mL (10.4 mmol) of methyl 2-hydroxy-isobutyrate in 50 mL of CH2Cl2 were added 1.2 g (17.6 mmol) of imidazole and 2.1 mL (16.6 mmol) of TMSCl. The mixture was stirred at r.t. for 1.5 h and quenched with 20 mL of H2O. The organic layer was dried over MgSO4, concentrated and passed through a short plug of silica gel eluted with 9:1 hexane/EtOAc. Evaporation of solvent afforded 1.27 g of the title compound as a colorless oil.
後処理
- customquenched with 20 mL of H2O
- dry with materialThe organic layer was dried over MgSO4
- concentrationconcentrated
- washeluted with 9:1 hexane/EtOAc
- customEvaporation of solvent
出典と根拠
- ORDレコード
- ord-939c233f54a54bfabcc151e65d9cfbd4
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05840746
関連ノート
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