Ethyl bromoacetate → 3-Carbethoxymethyl-2-methylthio-7-phenylpyrazolo [1,5-a]-1,3,5-triazine-4-one

HRID 35728ノート

反応式

HRID 35728 の反応式
[CH3:1][S:2][C:3]1[NH:8][C:7](=[O:9])[N:6]2[N:10]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:12]=[C:5]2[N:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:25]([O:27][C:28](=[O:31])[CH2:29]Br)[CH3:26]>CN(C)C=O>[C:28]([CH2:29][N:8]1[C:7](=[O:9])[N:6]2[N:10]=[C:11]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:12]=[C:5]2[N:4]=[C:3]1[S:2][CH3:1])([O:27][CH2:25][CH3:26])=[O:31]

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 135712889HCID 135712889、化合物

生成物 1

HCID 140994643-Carbethoxymethyl-2-methylthio-7-phenylpyrazolo [1,5-a]-1,3,5-triazine-4-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 260 mg of 2-methylthio-7-phenylpyrazolo [1,5-a]-1,3,5-triazine-4-one and 140 mg of anhydrous potassium carbonate in 5 ml dry dimethylformamide is stirred at room temperature for 15 min while 0.14 ml ethylbromacetate is added dropwise. The mixture is stirred at room temperature overnight, filtered, and the filter cake washed with dimethylformamide.

後処理

  1. additionis added dropwise
  2. filtrationfiltered
  3. washthe filter cake washed with dimethylformamide

出典と根拠

ORDレコード
ord-e18bd378688440c28bedfaf8b91e0186
出典データセット
uspto-grants-1988_08
特許番号
US04767858

反応ノート

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