Hexane → 2-Amino-3-hydroxybenzonitrile

HRID 357292

反応式

HRID 357292 の反応式
[N+:1]([C:4]1[C:11]([OH:12])=[CH:10][CH:9]=[CH:8][C:5]=1[C:6]#[N:7])([O-])=O.[H][H].CCCCCC.C(OCC)(=O)C>[Pd].C(O)C>[NH2:1][C:4]1[C:11]([OH:12])=[CH:10][CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

参加物

7

反応物 4

HCID 8058HexaneHCID 8857Ethyl AcetateHCID 138624233-Hydroxy-2-nitrobenzonitrileHCID 178418361HCID 178418361、化合物

生成物 1

HCID 159063362-Amino-3-hydroxybenzonitrile

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A parr bottle was charged with palladium on activated carbon (5%, 0.196g). A solution of 2-nitro-3-hydroxybenzonitrile (1.31 g, 0.008 mol) in 40 ml of ethanol was added. The reaction mixture was placed under 25 psi of hydrogen gas and shaken for 1 hour. TLC (1:1 hexane:ethyl acetate) shows that no starting material remained. The mixture was filtered through Celite® and evaporated to yield 2-amino-3-hydroxybenzonitrile, 1.01 g (0.0075 mol, 94%).

後処理

  1. filtrationThe mixture was filtered through Celite®
  2. customevaporated

出典と根拠

ORDレコード
ord-59f4430508a249a3b05078ccf53bc50f
出典データセット
uspto-grants-1998_11
特許番号
US05840764

関連ノート

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