1,4-Dibromobutane → 4-(4-Bromobutyl)-1-(1,3-dithian-2-yl)ethylbenzene

HRID 357391ノート

反応式

HRID 357391 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:10]2[S:15][CH2:14][CH2:13][CH2:12][S:11]2)[CH3:9])=[CH:4][CH:3]=1.C([Li])(CC)C.[Br:21][CH2:22][CH2:23][CH2:24][CH2:25]Br.C(OCC)(=O)C>O1CCCC1>[Br:21][CH2:22][CH2:23][CH2:24][CH2:25][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:10]2[S:15][CH2:14][CH2:13][CH2:12][S:11]2)[CH3:9])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 80561,4-DibromobutaneHCID 8857Ethyl AcetateHCID 219601124-Bromo-1-(1,3-dithian-2-yl)ethylbenzeneHCID 178418400CID 53628100

生成物 1

HCID 219601294-(4-Bromobutyl)-1-(1,3-dithian-2-yl)ethylbenzene

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4-bromo-1-(1,3-dithian-2-yl)ethylbenzene (27.2 g, 94 mmol) in tetrahydrofuran (200 ml) was charged with sec-butyllithium (99 ml, 1.3M in cyclohexane, 0.13 mole) dropwise at -78° C. under nitrogen. The mixture was stirred at ambient temperature for 1.5 hours, and then quenched with 1,4-dibromobutane (42 g, 0.2 mole). After being stirred for 3 hours, the mixture was poured into ethyl acetate, and then washed with water and brine. The organic solution was then dried (Na2SO4 and concentrated to an oil. The crude product was purified by flash chromatography over a silica gel column. The 4-(4-bromobutyl)-1-(1,3-dithian-2-yl)-ethylbenzene thus purified was a light oil, 22.3 g.

後処理

  1. stirringAfter being stirred for 3 hours
  2. washwashed with water and brine
  3. dry with materialThe organic solution was then dried (Na2SO4
  4. concentrationconcentrated to an oil
  5. customThe crude product was purified by flash chromatography over a silica gel column
  6. customThe 4-(4-bromobutyl)-1-(1,3-dithian-2-yl)-ethylbenzene thus purified

出典と根拠

ORDレコード
ord-f656645ccbce40c7a97fcdf96107c083
出典データセット
uspto-grants-1998_11
特許番号
US05840727

反応ノート

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