Hydrochloric Acid → (S)-1,1,3,4,4,6-hexamethyl1,2,3,4-tetrahydronaphthalene

HRID 35751

反応式

HRID 35751 の反応式
[H-].[Li+].[H-].[Li+].[Al+3].[H-].[H-].[H-].Cl[CH2:10][C@@H:11]1[C:20]([CH3:22])([CH3:21])[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([CH3:23])[CH:18]=2)[C:13]([CH3:25])([CH3:24])[CH2:12]1.Cl>O1CCCC1>[CH3:24][C:13]1([CH3:25])[C:14]2[C:19](=[CH:18][C:17]([CH3:23])=[CH:16][CH:15]=2)[C:20]([CH3:22])([CH3:21])[C@@H:11]([CH3:10])[CH2:12]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 62714Lithium hydrideHCID 13175029(S)-3-chloromethyl-1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthaleneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 13175223(S)-1,1,3,4,4,6-hexamethyl1,2,3,4-tetrahydronaphthalene収率 73%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of lithium hydride (4.52 g; 0.569 mol) and aluminum lithium hydride (1.81 g; 0.048 mol) in tetrahydrofuran under nitrogen, (S)-3-chloromethyl-1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene (94.69 g; 0.378 mol) was added dropwise, and the resultant mixture was heated while refluxing for 36 hours. The reaction mixture was treated with dilute hydrochloric acid and extracted with n-hexane. The extract was washed with saturated sodium chloride solution, dried, concentrated and distilled to give (S)-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (59.7 g; 0.276 mol).

後処理

  1. temperaturewhile refluxing for 36 hours
  2. extractionextracted with n-hexane
  3. washThe extract was washed with saturated sodium chloride solution
  4. customdried
  5. concentrationconcentrated
  6. distillationdistilled

出典と根拠

ORDレコード
ord-c06f0207e593442db845f254e6ee523b
出典データセット
uspto-grants-1988_08
特許番号
US04767882

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