Sodium Hydroxide → 2-Methyl-3-furoic acid

HRID 357782

反応式

HRID 357782 の反応式
C([O:3][C:4]([C:6]1[CH:10]=[CH:9][O:8][C:7]=1[CH3:11])=[O:5])C.[OH-].[Na+]>C(O)C>[CH3:11][C:7]1[O:8][CH:9]=[CH:10][C:6]=1[C:4]([OH:5])=[O:3]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 261900Ethyl 2-Methyl-3-furoate

生成物 1

HCID 2447562-Methyl-3-furoic acid収率 67.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Methyl-3-furancarboxylic acid ethyl ester (10 g) was dissolved in ethanol (70 ml), and 1N aqueous sodium hydroxide (78 ml) was added. The mixture was stirred at room temperature and concentrated under reduced pressure. The residue was dissolved in water and washed with diethyl ether. The aqueous layer was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Precipitated crystals were collected by filtration to give 2-methyl-3-furancarboxylic acid (5.5 g) as crystals.

後処理

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. washwashed with diethyl ether
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with water and saturated aqueous sodium chloride
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customPrecipitated crystals
  9. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-b933f011bb044043b97cfc5f3657c2dd
出典データセット
uspto-grants-1998_11
特許番号
US05840917

関連ノート

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