Water → Ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate

HRID 358024ノート

反応式

HRID 358024 の反応式
Br.[CH:2]1[N:6]2[C:7]3[C:12]([N:13]=[CH:14][C:5]2=[N:4][C:3]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=[CH:9][CH:8]=3.[BH4-].[Na+].O>C(O)C>[CH:2]1[N:6]2[C:7]3[C:12]([NH:13][CH2:14][C:5]2=[N:4][C:3]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=[CH:9][CH:8]=3

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 20450288HCID 20450288、化合物

生成物 1

HCID 13228326Ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate収率 99.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of 1.6 g of ethyl imidazo[1,2-a]quinoxaline-2-carboxylate hydrobromide (British patent application Ser. No. 79-26597, in 50 ml of ethanol was added portionwise 0.5 g of sodium borohydride and at the completion of the reaction (tlc), the mixture was poured into 250 ml of water. The mixture was extracted with ethyl acetate and the organic layer was washed with water, dried and evaporated to dryness to obtain 1.2 g (97% yield) of ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2-carboxylate melting at 206°-8° C.

後処理

  1. customat the completion of the reaction (tlc)
  2. extractionThe mixture was extracted with ethyl acetate
  3. washthe organic layer was washed with water
  4. customdried
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-2947693e804a48768ca870206a4868c0
出典データセット
uspto-grants-1984_08
特許番号
US04464373

反応ノート

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