Ethyl chloroformate → Diethyl imidazo[1,2-a]quinoxaline-2,5(4H)-dicarboxylate

HRID 358026ノート

反応式

HRID 358026 の反応式
[CH:1]1[N:5]2[C:6]3[C:11]([N:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:13][C:4]2=[N:3][CH:2]=1)=[CH:10][CH:9]=[CH:8][CH:7]=3.Cl[C:20]([O:22][CH2:23][CH3:24])=[O:21]>CN(C)C=O>[CH:1]1[N:5]2[C:6]3[C:11]([N:12]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:13][C:4]2=[N:3][C:2]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:10][CH:9]=[CH:8][CH:7]=3

参加物

4

反応物 2

HCID 10928Ethyl chloroformateHCID 20450291HCID 20450291、化合物

生成物 1

HCID 13228332Diethyl imidazo[1,2-a]quinoxaline-2,5(4H)-dicarboxylate収率 76%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 1.0 g of ethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-5-carboxylate in 5 ml of dry dimethylformamide was treated with 0.5 g of ethyl chloroformate and the mixture was stirred at room temperature. After 2 hours, the mixture was set solid, was filtered and the residue was triturated with water and chromatographed over silica gel with ethyl acetate as eluant to obtain 0.98 g (76% yield) of diethyl 4,5-dihydroimidazo[1,2-a]quinoxaline-2,5-dicarboxylate melting at 151°-3° C.

後処理

  1. filtrationwas filtered
  2. customthe residue was triturated with water
  3. customchromatographed over silica gel with ethyl acetate as eluant

出典と根拠

ORDレコード
ord-7ce5789654ae4942bacfe37cc941ecbf
出典データセット
uspto-grants-1984_08
特許番号
US04464373

反応ノート

読み込み中…