Ammonia → 4-(2-Fluorophenyl)-4-phenylbutanoicacid

HRID 358042

反応式

HRID 358042 の反応式
[CH:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[C:13]([F:14])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:3][CH:2]=1.N.[Na].Br[CH2:18][CH2:19][C:20]([OH:22])=[O:21].Cl>CCOCC.[N+]([O-])([O-])=O.[Fe+3].[N+]([O-])([O-])=O.[N+]([O-])([O-])=O>[F:14][C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH:7]([C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1)[CH2:18][CH2:19][C:20]([OH:22])=[O:21]

参加物

8

反応物 5

HCID 222Ammonia2 回HCID 313Hydrochloric AcidHCID 115533-Bromopropionic acidHCID 1380532-FluorodiphenylmethaneHCID 5360545Sodium2 回

生成物 1

HCID 204500254-(2-Fluorophenyl)-4-phenylbutanoicacid

試薬・触媒・溶媒 2

HCID 25251Ferric nitrate触媒HCID 3283Diethyl Ether溶媒

実験手順

100 g of 2-fluorodiphenylmethane are slowly added dropwise to a solution of sodiuum amide which has been prepared from 500 ml of liquid ammonia, 0.22 g of iron (III) nitrate and 13.2 g of sodium. After 10 minutes, a solution of 40.75 g of 3-bromopropionic acid in 500 ml of ether is added dropwise. After a further 15 minutes, the ammonia is allowed to distill off. The crystallized-out sodium salt of 4-(2-fluorophenyl)-4-phenylbutyric acid is filtered off and washed with ether. The free acid is obtained by treating the sodium salt with dilute hydrochloric acid, extracting the mixture with ether and evaporating the ethereal solution. There is obtained 4-(2-fluorophenyl)-4-phenylbutyric acid of melting point 105°.

後処理

  1. waitAfter a further 15 minutes
  2. distillationto distill off
  3. filtrationThe crystallized-out sodium salt of 4-(2-fluorophenyl)-4-phenylbutyric acid is filtered off
  4. washwashed with ether
  5. customThe free acid is obtained
  6. extractionextracting the mixture with ether
  7. customevaporating the ethereal solution

出典と根拠

ORDレコード
ord-deef2fb43cb5454fa132c07bd98a3f18
出典データセット
uspto-grants-1984_08
特許番号
US04464300

関連ノート

読み込み中…