Nonanoyl chloride → N,N-bis(Pelargonoyloxyethyl)pelargonoylacetamide

HRID 358100

反応式

HRID 358100 の反応式
[C:1](Cl)(=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[OH:12][CH2:13][CH2:14][N:15]([CH2:20][CH2:21][OH:22])[C:16](=[O:19])[CH2:17]O>N1C=CC=CC=1>[C:1]([O:22][CH2:21][CH2:20][N:15]([CH2:14][CH2:13][O:12][C:1](=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[C:16](=[O:19])[CH2:17][C:1](=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])(=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

4

反応物 2

HCID 69819Nonanoyl chlorideHCID 87097N,N-Bis(2-hydroxyethyl)glycolamide

生成物 1

HCID 86738544N,N-bis(Pelargonoyloxyethyl)pelargonoylacetamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

106 g (0.6 mole) of pelargonoyl chloride was added dropwise with stirring to a solution of 32.6 g (0.2 mole) of N,N-bis(hydroxyethyl)hydroxyacetamide in 60 ml of pyridine. The precipitated pyridine hydrochloride was filtered, washed with benzene, and discarded. The benzene solution of product was water washed, dried over sodium sulfate, and passed through an activated alumina column to remove any acid. The benzene was stripped off on a rotary evaporator. The yield of product was essentially quantitative. Its structure was established by infrared and nuclear magnetic resonance spectroscopy. It had n30D 1.4537 and d304 0.9745.

後処理

  1. filtrationThe precipitated pyridine hydrochloride was filtered
  2. washwashed with benzene
  3. washwashed
  4. dry with materialdried over sodium sulfate
  5. customto remove any acid
  6. customThe benzene was stripped off on a rotary evaporator

出典と根拠

ORDレコード
ord-d17743856c89465dbf52a6034e429adb
出典データセット
uspto-grants-1984_08
特許番号
US04464392

関連ノート

読み込み中…