Ethanol → N,N'-Dicyclohexylurea

HRID 358109ノート

反応式

HRID 358109 の反応式
C(CC(OC1C=[C:10]([C:14]2[N:15]=[C:16]3[N:20]([CH:21]=2)[C:19]2[CH:22]=[CH:23][CH:24]=[CH:25][C:18]=2S3)[CH:11]=[CH:12][CH:13]=1)=O)(O)=O.C([OH:28])C.C1(N=C=NC2CCCCC2)CCCCC1>O1CCCC1>[CH:19]1([NH:20][C:16]([NH:15][CH:14]2[CH2:10][CH2:11][CH2:12][CH2:13][CH2:21]2)=[O:28])[CH2:18][CH2:25][CH2:24][CH2:23][CH2:22]1

参加物

5

反応物 3

HCID 702EthanolHCID 10868DicyclohexylcarbodiimideHCID 137307YM 13650

生成物 1

HCID 4277N,N'-Dicyclohexylurea

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a mixture of 4 g of 2-(m-carboxyacetoxyphenyl)imidazo[2,1-b]benzothiazole, 0.52 g of ethanol, and 50 ml of tetrahydrofuran was added a mixture of 2.3 g of dicyclohexylcarbodiimide and 10 ml of tetrahydrofuran at a temperature below 10° C. Thereafter, the mixture was stirred overnight at room temperature. Dicyclohexyl urea thus formed was filtered off and the filtrate was concentrated under reduced pressure. The residue was applied to silica gel column chromatography (80 ml of silica gel, eluate: a mixture of toluene and ethyl acetate (9:1)) to provide 2.0 g of oily 2-(m-ethoxycarbonylacetoxyphenyl)imidazo[2,1-b]benzothiazole.

後処理

  1. additionwas added

出典と根拠

ORDレコード
ord-d527bffdb09447ec874148bbd199ad2e
出典データセット
uspto-grants-1984_08
特許番号
US04464384

反応ノート

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