5-Methyl-4-(4-nitro-phenyl)-imidazole → 4-(5-Methyl-1H-imidazol-4-yl)aniline

HRID 358256ノート

反応式

HRID 358256 の反応式
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1.[H][H]>CO.[Pd]>[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 235073515-Methyl-4-(4-nitro-phenyl)-imidazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 235076304-(5-Methyl-1H-imidazol-4-yl)aniline収率 88%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Sixty grams of 5-methyl-4-(4-nitrophenyl)-1-H-imidazole dissolved in methanol was hydrogenated in the presence of 0.7 gm of 5% Pd catalyst at atmospheric pressure and at room temperature. When the calculated amount of hydrogen was taken up, the catalyst was filtered off, and the solution was evaporated to dryness to yield 45 gm of 5-methyl-4-(4-aminophenyl)-1-H-imidazole.

後処理

  1. filtrationthe catalyst was filtered off
  2. customthe solution was evaporated to dryness

出典と根拠

ORDレコード
ord-daca8089e70f4649b3ff7cc9b46cebfc
出典データセット
uspto-grants-1984_08
特許番号
US04465841

反応ノート

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