Sodium Hydroxide → HCID 178484896、化合物

HRID 358257ノート

反応式

HRID 358257 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.Cl.[CH3:14][N:15]=[CH:16]OCC.[OH-].[Na+]>C(O)C>[CH3:14][NH:15][CH:16]=[N:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 12210271ethyl N-methyl-formimidate hydrochlorideHCID 178507418HCID 178507418、化合物

生成物 1

HCID 178484896HCID 178484896、化合物収率 34.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A suspension of 0.8 gm of 4-(4-aminophenyl)-1-H-imidazole and 1.86 gm of ethyl N-methyl-formimidate hydrochloride [F. H. Suydam et al., J. Org. Chem. 34, 292 (1969)] in 20 ml of anhydrous ethanol was stirred at room temperature for two days. The clear solution was evaporated to dryness, and the oily residue was dissolved in water. The solution so obtained was adjusted to pH 10 with 10% NaOH. The product which separated was extracted with ethyl acetate, the organic solution was evaporated to dryness, and the product obtained was purified through its hydorchloride salt to give 0.35 gm of the desired compound as crystalline solid.

後処理

  1. customThe clear solution was evaporated to dryness
  2. dissolutionthe oily residue was dissolved in water
  3. customThe solution so obtained
  4. customThe product which separated
  5. extractionwas extracted with ethyl acetate
  6. customthe organic solution was evaporated to dryness
  7. customthe product obtained
  8. customwas purified through its hydorchloride salt

出典と根拠

ORDレコード
ord-d3b976f6f6d8451c91d2eac5a94e0ee4
出典データセット
uspto-grants-1984_08
特許番号
US04465841

反応ノート

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