2-Hydroxy-4-methyl-hydratropic acid phenylurethane → 2-(4-Tolyl)propanoic acid

HRID 358286

反応式

HRID 358286 の反応式
C1(NC(OCC)=O)C=CC=CC=1.O[C:14]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:15]=1[CH:16]([CH3:20])[C:17]([OH:19])=[O:18].[H][H]>C(O)(=O)C.[Pd]>[CH3:25][C:23]1[CH:22]=[CH:21][C:15]([CH:16]([CH3:20])[C:17]([OH:19])=[O:18])=[CH:14][CH:24]=1

参加物

5

反応物 2

HCID 705129172-Hydroxy-4-methyl-hydratropic acid phenylurethaneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 1508662-(4-Tolyl)propanoic acid収率 67%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

3 g. of 2-hydroxy-4-methyl-hydratropic acid phenylurethane are dissolved in acetic acid. To the solution 0.4 g. of a 5% palladium-on-charcoal catalystand the mixture is hydrogenated at 25° C. until the calculated amount of hydrogen is used up. The catalyst is filtered off and the filtrate is evaporated. The residue is admixed with a 10% aqueous hydrochloric acid solution and the separated oil is extracted with chloroform. The chloroform solution is dried over sodium sulphate and evaporated. 1.1 g. (67%) of 4-methyl-hydratropic acid are obtained.

後処理

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated
  3. extractionthe separated oil is extracted with chloroform
  4. dry with materialThe chloroform solution is dried over sodium sulphate
  5. customevaporated

出典と根拠

ORDレコード
ord-63815bf459344ee2a79fc079d2e70945
出典データセット
uspto-grants-1984_08
特許番号
US04465855

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