Methyl Isocyanate → N,2-Dimethyl-2,3-dihydro-1H-indole-1-carboxamide

HRID 358329

反応式

HRID 358329 の反応式
[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[CH3:11][N:12]=[C:13]=[O:14]>C1(C)C=CC=CC=1>[CH3:11][NH:12][C:13]([N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:10][CH:2]1[CH3:1])=[O:14]

参加物

4

反応物 2

HCID 12228Methyl IsocyanateHCID 233052-Methylindoline

生成物 1

HCID 12321965N,2-Dimethyl-2,3-dihydro-1H-indole-1-carboxamide収率 89%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

1 mole of 2-methylindoline is dissolved in 300 ml of toluene and 1 mole of methyl isocyanate is added, the temperature not rising above 25° C. The mixture is left to stand for 1 day and the resulting precipitate is then filtered off. N-Methylaminocarbonyl-2-methylindoline with a melting point of 158°-160° C. is obtained. Yield: 89% of theory.

後処理

  1. customrising above 25° C
  2. waitThe mixture is left
  3. filtrationthe resulting precipitate is then filtered off

出典と根拠

ORDレコード
ord-301534f4b203478c9dc009a74deb5d9e
出典データセット
uspto-grants-1984_08
特許番号
US04466964

関連ノート

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